Sitagliptin + Metformin Tablet 50-500 mg

$500.00

Sitagliptin + Metformin Tablets 50-500 mg is a combination oral antidiabetic medication designed for the effective management of type 2 diabetes mellitus. This dual-action formulation combines Sitagliptin, a DPP-4 inhibitor, with Metformin, a biguanide. Sitagliptin enhances the body’s natural incretin hormones to increase insulin production and reduce glucagon release, leading to better blood sugar regulation. Metformin reduces hepatic glucose production and improves insulin sensitivity, providing complementary mechanisms for optimal glycemic control. This combination is particularly effective in patients whose blood sugar levels are not adequately managed with Metformin alone.

Recommended Usage:

  • Indications:
    • Management of type 2 diabetes mellitus in adults, particularly in patients inadequately controlled with diet, exercise, and Metformin monotherapy.
    • Can also be used as an adjunct to other antidiabetic agents for comprehensive blood glucose management.
  • Dosage and Administration:
    • Typically taken twice daily with meals to minimize gastrointestinal side effects and reduce the risk of hypoglycemia.
    • Starting dose and dosage adjustments depend on the patient’s current regimen, blood glucose levels, and tolerability.
    • Maximum daily dose should not exceed 100 mg of Sitagliptin and 2000 mg of Metformin.
    • Regular blood glucose monitoring is essential to adjust the dose and prevent complications.
  • Precautions:
    • Not recommended for patients with type 1 diabetes, diabetic ketoacidosis, severe renal or hepatic impairment, or known hypersensitivity to Sitagliptin or Metformin.
    • Monitor for signs of lactic acidosis, particularly in patients with renal impairment or conditions that predispose them to hypoxia.
    • Avoid excessive alcohol consumption to reduce the risk of lactic acidosis.
    • Use in pregnancy or breastfeeding should be under medical supervision.
    • Periodic assessment of kidney function is recommended during therapy.
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Description

Key Benefits:

  • Dual Mechanism for Glycemic Control: Combines the incretin-enhancing effects of Sitagliptin with the glucose-lowering benefits of Metformin for comprehensive blood sugar regulation.
  • Effective in Combination Therapy: Provides superior glycemic control compared to monotherapy, especially in patients with inadequately controlled diabetes.
  • Reduced Risk of Hypoglycemia: Sitagliptin works in a glucose-dependent manner, reducing the likelihood of hypoglycemia.
  • Convenient Dosing: Combines two active ingredients into a single tablet, simplifying diabetes management.
  • Proven Safety Profile: Backed by clinical studies demonstrating efficacy and safety in the management of type 2 diabetes.

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